Writer/director Guy Ritchie continues in mockney gangster vein with this follow-up to his 1998 hit ´Lock, Stock and Two Smoking Barrels´. In London, en route to deliver a stolen diamond to his employer Avi (Dennis Farina), thief Franky Four Fingers (Benicio Del Toro) is ambushed by Russian mobster Boris the Blade (Rade Sherbedgia). At the same time, boxing promoters Turkish (Jason Statham) and Tommy (Stephen Graham) enter Irish gypsy fighter Mickey (Brad Pitt) in a fight run by local kingpin Brick Top (Alan Ford). Instead of throwing the fight as arranged, Mickey earns Brick Top´s enmity by beating his opponent fair and square. Meanwhile, Avi travels to London and hires Bullet Tooth Tony (Vinnie Jones) to track down Franky and the diamond - which Brick Top has now found out about and decided to appropriate from Boris!