This book provides a comprehensive overview of manufacturing systems, their role in product/process design, and their interconnection with an Industry 4.0 perspective, especially related to design, manufacturing, and operations. Handbook of Manufacturing Systems and Design: An Industry 4.0 Perspective provides the knowledge related to the theories and concepts of Industry 4.0. It focuses on the different types of manufacturing systems in Industry 4.0 along with associated design, and control strategies. It concentrates on the operations in Industry 4.0 with a particular focus on supply chain, logistics, risk management, and reverse engineering perspectives. Offering basic concepts and applications through to advanced topics, the handbook feeds into the goal of being a source of knowledge as well as a vehicle to explore the future possibilities of design, techniques, methods, and operations associated with Industry 4.0. Concepts with practical applications in the form of case studies are added to each chapter to round out the many attributes this handbook offers. This handbook targets students, engineers, managers, designers, and manufacturers, and will assist in their understanding of the core concepts of manufacturing systems in connection with Industry 4.0 and optimize alignment between supply and demand in real time for effective implementation of the design concepts.