Emotions are dangerous, which is why the graduates of Moscow´s famed spy school the Red Room are taught to keep their enemies close and their loved ones at a distance. Black Widow and Red Widow, also known as Natasha Romanoff and Ava Orlova, forgot that lesson once, and they won´t forget it again. Once again, nothing is as it seems, no one can be trusted, and no one is safe - not unless the Widows can stop a conspiracy involving stolen nuclear warheads, mind-altering chemical weapons, and ultimately, betrayal by old friends and enemies alike.